Listar por autor "Novick, Richard P."

Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus

Maiques, Elisa; Ubeda, Carles; Campoy Sánchez, Susana; Salvador, Noelia; Lasa Uzcudun, Íñigo

; Novick, Richard P.; Barbé, Jordi; Penadés, José R. (American Society for Microbiology, 2006) Artículo / Artikulua

Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...

Killing niche competitors by remote-control bacteriophage induction

Selva, Laura; Viana, David; Regev Yochay, Gili; Trzcinski, Krzysztof; Corpa, Juan Manuel; Lasa Uzcudun, Íñigo

; Novick, Richard P.; Penadés, José R. (National Academy of Sciences, 2009) Artículo / Artikulua

A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ...

Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands

Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo

; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010) Artículo / Artikulua

Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ...

RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria

Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo

; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011) Artículo / Artikulua

Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...

Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer

Maiques, Elisa; Ubeda, Carles; Tormo Más, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo

; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007) Artículo / Artikulua

SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ...

Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins

Tormo Más, María Ángeles; Ferrer, María Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa Uzcudun, Íñigo

; Calvete, Juan J.; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2008) Artículo / Artikulua

Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small ...

A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria

Quiles Puchalt, Nuria; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Toledo Arana, Alejandro

; Monedero, Vicente; Lasa Uzcudun, Íñigo

; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2013) Artículo / Artikulua

The propagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mechanisms involved in virion assembly and DNA packaging. Here, we identified and characterized four different families ...